Factor XIII
Factor XIII deficiency is an inherited bleeding disorder that is caused by a problem with factor XIII. The body produces less factor XIII than it should or because the factor XIII is not working properly; the clotting reaction is blocked prematurely and the blood clot does not form.
Factor XIII deficiency is an autosomal recessive disorder, which means that both parents must carry the defective gene in order to pass it on to their child. This also means that the disorder affects both males and females. Factor XIII deficiency is the rarest factor deficiency, occurring in 1 per 5 million births, but like all autosomal recessive disorders, it is found more frequently in areas of the world where marriage between close relatives is common.
